San Francisco 49ers Schedule
2009-2010 Pro Football Schedule
| Week 1 - 49ers @ Cardinals |
| Week 2 - 49ers vs. Seahawks |
| Week 3 - 49ers @ Vikings |
| Week 4 - 49ers vs. Rams |
| Week 5 - 49ers vs. Falcons |
| Week 6 - BYE |
| Week 7 - 49ers @ Texans |
| Week 8 - 49ers @ Colts |
| Week 9 - 49ers vs. Titans |
| Week 10 - 49ers vs. Bears |
| Week 11 - 49ers @ Packers |
| Week 12 - 49ers vs. Jaguars |
| Week 13 - 49ers @ Seahawks |
| Week 14 - 49ers vs. Cardinals |
| Week 15 - 49ers @ Eagles |
| Week 16 - 49ers vs. Lions |
| Week 17 - 49ers @ Rams |